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Updated: Jan 1, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
Immunometabolic disorders in the pathogenesis of systemic lupus erythematosus
Kamila Tokarska1, Ireneusz Majsterek2, Magda Cuchra2
1Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland.
Abstract:
Systemic lupus erythematosus is a chronic autoimmune disease connected with complex and unclear disorders of the immune system, which causes inflammation of body tissues and internal organs. It leads to the formation of anti-nuclear antibodies (ANA) and immune complexes. Numerous immune system disorders and dysfunctions in the biochemical processes can occur in the course of the disease, and a wide range of abnormalities associated with cellular respiratory processes and mitochondrial function have been documented. The following paper presents the current understanding of the contribution of these disorders to the pathogenesis of lupus.
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