Palladium-catalyzed Sonogashira coupling reactions in γ-valerolactone-based ionic liquids
László Orha1,2, József M Tukacs1, László Kollár3
1Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics Műegyetem rkp. 3, Budapest, H-1111, Hungary.
Abstract:
It was demonstrated that the γ-valerolactone-based ionic liquid, tetrabutylphosphonium 4-ethoxyvalerate as a partially bio-based solvent can be utilized as alternative reaction medium for copper- and auxiliary base-free Pd-catalyzed Sonogashira coupling reactions of aryl iodides and functionalized acetylenes under mild conditions. Twenty-two cross-coupling products were isolated with good to excellent yields (72-99%) and purity (>98%). These results represent an example which proves that biomass-derived safer solvents can be utilized efficiently in common, industrially important transformations exhibiting higher chemical and environmental efficiency.
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