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Serum adenosine deaminase activity and coronary artery disease: a retrospective case-control study based on 9929

Chao Xuan1, Qing-Wu Tian2, Shao-Yan Zhang2

  • 1Department of Clinical Laboratory, The Affiliated Hospital of Qingdao University, 59, Haier Road, Qingdao 266101, China.

Therapeutic Advances in Chronic Disease
|December 17, 2019
PubMed

Insights

Serum adenosine deaminase (ADA) activity is lower in patients with coronary artery disease (CAD), especially myocardial infarction (MI). This finding suggests ADA may play a protective role in cardiovascular health.

Area of Science:

  • Biochemistry
  • Cardiology
  • Metabolic Disorders

Background:

  • Adenosine deaminase (ADA) is crucial for purine metabolism, converting adenosine to uric acid (UA).
  • Both adenosine and UA are linked to cardiovascular events.
  • The relationship between serum ADA activity and coronary artery disease (CAD) remains unclear.

Purpose of the Study:

  • To investigate the correlation between serum ADA activity and the presence of CAD.
  • To explore the role of ADA in cardiovascular disease pathogenesis.

Main Methods:

  • A hospital-based retrospective case-control study involving 5212 CAD patients and 4717 matched controls.
  • Serum ADA activity was measured using peroxidase assays on an automatic biochemistry analyzer.

Main Results:

  • Serum ADA activity was significantly lower in CAD patients (10.08 ± 3.57 U/l) compared to controls (11.71 ± 4.20 U/l).
  • Lower ADA activity negatively correlated with CAD presence (OR = 0.852, p < 0.001) after adjustments.
  • Patients with myocardial infarction (MI) exhibited the lowest ADA activity (9.77 ± 3.80 U/l).
  • Diabetes and hypertension were associated with increased ADA activity in CAD patients.

Conclusions:

  • Serum ADA activity is significantly reduced in CAD patients, particularly those with MI.
  • This suggests a potential compensatory mechanism involving adenosine levels to protect the cardiovascular system during CAD.
Abstract

Keywords:
adenosineadenosine deaminasecoronary artery disease

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