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Published on: September 9, 2011
Interferon gamma inducible protein 16 (IFI16) expression is reduced in mantle cell lymphoma
Pier Paolo Piccaluga1,2,3, Mohsen Navari4,5,6, Axel Visani1
1Department of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, Bologna, Italy.
Abstract:
IFI16, member of the IFN-inducible PYHIN-200 gene family, modulates proliferation, survival and differentiation of different cell lineages. In particular, IFI16 expression, which is regulated during the differentiation of B cells, was recently studied in B-CLL as well. Here, we compared IFI16 expression in several lymphomas including Burkitt lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma and mantle cell lymphoma with respect to normal cell counterparts. We observed that IFI16 expression was significantly deregulated only in mantle cell lymphoma (p < 0.05). Notably, IFI16 was associated with the expression of genes involved in interferon response, cell cycle, cell death and proliferation and, interestingly, lipid and glucose metabolism, suggesting that IFI16 deregulation might be associated with relevant changes in cell biology. In our group of mantle cell lymphoma samples a correlation between patient survival and IFI16 expression was not detected even though mantle cell lymphoma prognosis is known to be associated with cell proliferation. Altogether, these results suggest a complex relationship between IFI16 expression and MCL which needs to be analyzed in further studies.
Insights
Interferon gamma (IFN)-inducible protein 16 (IFI16) expression is deregulated in mantle cell lymphoma (MCL). This deregulation impacts cell biology, but not patient survival in MCL.
Area of Science:
- Immunology
- Oncology
- Molecular Biology
Background:
- Interferon gamma (IFN)-inducible protein 16 (IFI16) is part of the PYHIN-200 gene family and influences cell proliferation, survival, and differentiation.
- IFI16 expression is regulated during B cell differentiation and has been investigated in B-cell chronic lymphocytic leukemia (B-CLL).
Purpose of the Study:
- To compare IFI16 expression across various lymphomas, including Burkitt lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma, and mantle cell lymphoma (MCL), against normal cell counterparts.
- To investigate the association of IFI16 expression with cellular processes and patient survival in MCL.
Main Methods:
- Quantitative analysis of IFI16 gene expression in different lymphoma subtypes and normal B cells.
- Correlation analysis between IFI16 expression and genes involved in interferon response, cell cycle, apoptosis, proliferation, and metabolism.
- Assessment of the relationship between IFI16 expression and patient survival in MCL.
Main Results:
- IFI16 expression was significantly deregulated exclusively in mantle cell lymphoma (MCL) (p < 0.05).
- IFI16 expression correlated with genes related to interferon response, cell cycle, cell death, proliferation, and notably, lipid and glucose metabolism.
- No correlation was found between IFI16 expression and patient survival in the studied MCL cohort, despite MCL prognosis being linked to proliferation.
Conclusions:
- IFI16 deregulation in MCL suggests potential alterations in cell biology, including metabolism and cell cycle regulation.
- The complex relationship between IFI16 and MCL warrants further investigation, particularly concerning its role in disease pathogenesis and prognosis.
- While IFI16 expression is altered in MCL, its direct impact on patient survival in this cohort was not evident, indicating a nuanced role.
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