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Link between omentin-1, obesity and insulin resistance in children: Findings from a longitudinal intervention study

Juliane Rothermel1, Nina Lass1, Andre Barth1

  • 1Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Datteln, Germany.

Pediatric Obesity
|December 17, 2019
PubMed

Insights

Omentin-1 levels are lower in children with obesity but increase with weight loss, suggesting it links obesity and insulin resistance. This adipokine

Area of Science:

  • Endocrinology
  • Pediatric Obesity
  • Metabolic Health

Background:

  • Omentin-1, an adipokine, is hypothesized to be inversely associated with obesity and insulin resistance.
  • Understanding omentin-1's role in pediatric obesity is crucial for metabolic health interventions.

Purpose of the Study:

  • To investigate the relationship between omentin-1 levels and parameters of fat mass, insulin resistance, lipids, and blood pressure in children with obesity.
  • To examine the longitudinal changes in omentin-1 concentrations in response to a lifestyle intervention in children with obesity.

Main Methods:

  • Analyzed omentin-1 concentrations in normal-weight children and children with obesity over a one-year lifestyle intervention.
  • Measured various metabolic parameters including body composition, insulin resistance (HOMA-IR), lipids, and blood pressure at baseline and follow-up.

Main Results:

  • Omentin-1 concentrations were significantly lower in children with obesity compared to normal-weight children.
  • Omentin-1 levels increased significantly with substantial weight loss during and after the intervention.
  • Omentin-1 showed a significant negative association with insulin resistance (HOMA-IR) in both cross-sectional and longitudinal analyses.

Conclusions:

  • Omentin-1 levels are reversibly decreased in pediatric obesity.
  • Omentin-1 may serve as a crucial link between obesity and the development of insulin resistance in children.
  • Weight loss interventions can positively impact omentin-1 levels, highlighting its potential as a therapeutic target.
Abstract

Keywords:
bioactive leptininsulin resistancelifestyle interventionweight loss

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