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Analyzing the Size, Shape, and Directionality of Networks of Coupled Astrocytes
Published on: October 4, 2018
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Regulation of rhythmic behaviors by astrocytes
F Rob Jackson1, Samantha You1, Lauren B Crowe1
1Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts.
Wiley Interdisciplinary Reviews. Developmental Biology
|December 17, 2019
Summary
Astrocytes, a type of glial cell, possess internal circadian clocks that regulate rhythmic behaviors and sleep. Research in fruit flies and mice highlights their crucial role in controlling these biological rhythms.
Area of Science:
- Neuroscience
- Chronobiology
- Cell Biology
Background:
- Glial astrocytes are key regulators of nervous system development, physiology, and behavior across species.
- Astrocytes in the adult brain exhibit conserved circadian clocks.
- Previous studies indicate glial cell involvement in regulating circadian behavior and sleep.
Purpose of the Study:
- To review recent findings on the role of astrocytes and their endogenous circadian clocks in controlling rhythmic behavior.
- To highlight research utilizing Drosophila and mouse models.
Main Methods:
- Review of recent scientific literature.
- Comparative analysis of astrocyte function in Drosophila and mouse models.
Main Results:
- Astrocytes and their intrinsic circadian clocks are integral to the control of rhythmic behaviors.
- Evidence from both invertebrate (Drosophila) and vertebrate (mouse) models supports this conclusion.
Conclusions:
- Astrocytes play a significant role in the regulation of circadian rhythms and sleep.
- The function of endogenous astrocyte circadian clocks is conserved across diverse species.
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