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PCSK9 E670G polymorphism increases risk of coronary artery disease in a Chinese Han population

Zhang Lin1, Shi Hong Wang1, Da Yong Wei1

  • 1Department of Cardiology, Fujian Provincial Geriatric Hospital, Fujian Provincial Hospital North Branch, Fujian, China.

The Journal of International Medical Research
|December 17, 2019
PubMed

Insights

The PCSK9 E670G genotype is linked to an increased risk of coronary artery disease (CAD). This genetic variation may contribute to CAD development, highlighting its potential role in cardiovascular health.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Molecular Biology

Background:

  • Coronary artery disease (CAD) is a major global health concern, responsible for significant morbidity and mortality.
  • Low-density lipoprotein cholesterol levels are a known risk factor for CAD.
  • The proprotein convertase subtilisin/kexin type 9 (PCSK9) E670G polymorphism has been implicated in variations of LDL cholesterol but its direct link to CAD requires further investigation.

Purpose of the Study:

  • To investigate the association between the PCSK9 E670G polymorphism and the risk of developing coronary artery disease (CAD).
  • To clarify the relationship between this specific genetic variation and CAD through case-control studies and meta-analysis.

Main Methods:

  • Genotyping of the PCSK9 E670G polymorphism in 225 patients and 189 controls using DNA extracted from peripheral blood.
  • Statistical analysis including logistic regression to assess the risk associated with different genotypes.
  • Meta-analysis of 13 existing case-control studies to consolidate evidence on the PCSK9 E670G polymorphism and CAD risk.

Main Results:

  • The GG genotype of the PCSK9 E670G polymorphism was significantly associated with an increased risk of CAD (OR 2.994, 95% CI: 1.174-7.631), even after adjusting for other risk factors (OR 2.794, 95% CI: 1.215-7.460).
  • Logistic regression indicated that the dominant genetic model for PCSK9 E670G increased CAD risk (OR 2.313, 95% CI: 1.070-6.983) after accounting for confounding factors.
  • The meta-analysis of 13 studies confirmed a correlation between the PCSK9 E670G polymorphism and CAD risk across various genetic models.

Conclusions:

  • The PCSK9 E670G genotype is demonstrably associated with a high risk of coronary artery disease.
  • This finding underscores the potential role of PCSK9 genetic variations in the pathogenesis of CAD.
Abstract

Keywords:
CADCoronary artery diseasePCSK9low density lipoprotein cholesterolpolymorphismproprotein convertase subtilisin/kexin type 9

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