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Eptinezumab for the treatment of migraine

D Scuteri1, M T Corasaniti2, P Tonin3

  • 1Preclinical and Translational Pharmacology, Department of Pharmacy, Health Science and Nutrition, University of Calabria, Cosenza, Italy.

Drugs of Today (Barcelona, Spain : 1998)
|December 17, 2019
PubMed

Eptinezumab (ALD-403) is a genetically engineered humanized IgG1kappa directed towards calcitonin gene-related peptide (CGRP), currently in late-stage clinical development. Eptinezumab targets the pathway of CGRP, importantly implicated in migraine pathophysiology, and may represent the first-to-market infusion therapy for migraine prevention. The background for its approval consists in preclinical data and clinical trials. Here, we provide a comprehensive review of molecular pharmacology, pharmacokinetics, metabolism, efficacy and safety investigated in the preclinical and clinical studies, with insight on possible future directions.

Keywords:
ALD-403Analgesic drugsAnti-calcitonin gene-related peptide (CGRP) treatmentsEptinezumabMigraineMonoclonal antibodies

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