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Chronic Chagastic cardiomyopathy associated with membranoproliferative glomerulonephritis: Report of an autopsy case

Masayuki Shintaku1, Shinsaku Takeda2, Sachio Miura3

  • 1Department of Pathology, Shiga General Hospital, Shiga, Japan.

Pathology International
|December 17, 2019
PubMed

Insights

This autopsy report details a case of chronic Chagas disease in a 73-year-old woman, revealing cardiac and kidney damage. The study suggests Trypanosoma cruzi infection may contribute to kidney disease in chronic Chagas patients.

Area of Science:

  • Pathology
  • Infectious Diseases
  • Cardiology

Background:

  • Chagas disease, caused by Trypanosoma cruzi, is a significant global health concern.
  • Chronic infection can lead to debilitating cardiac complications, known as Chagasic cardiomyopathy.
  • The potential link between Trypanosoma cruzi infection and kidney disease remains an area of investigation.

Observation:

  • An autopsy was performed on a 73-year-old Brazilian woman of Japanese descent with a history of chronic Chagas disease.
  • The patient presented with cardiac insufficiency and autopsy revealed features consistent with chronic Chagasic cardiomyopathy, including myocarditis, fibrosis, and apical aneurysm.
  • Kidney examination showed membranoproliferative glomerulonephritis (MPGN).

Findings:

  • Despite symptoms of chronic Chagas disease, Trypanosoma cruzi protozoa were not detected in the cardiac tissue.
  • The autopsy findings in the heart were characteristic of chronic Chagasic cardiomyopathy.
  • The patient's kidney pathology demonstrated membranoproliferative glomerulonephritis (MPGN).

Implications:

  • This case supports the hypothesis that chronic Trypanosoma cruzi infection can trigger immune complex-mediated glomerulonephritis.
  • The findings suggest a potential role for persistent Trypanosoma cruzi infection in the pathogenesis of MPGN.
  • Further research is warranted to elucidate the mechanisms linking Chagas disease to renal pathology.

Keywords:
chronic Chagastic cardiomyopathymembranoproliferative glomerulonephritistrypanosoma cruzi

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