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Updated: Jan 1, 2026
06:28
Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
Published on: June 4, 2020
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Evaluating hypercoagulability in new-onset systemic lupus erythematosus patients using thromboelastography.
Huiyun Gong1, Ce Shi1, Zhuochao Zhou2
1Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal of Clinical Laboratory Analysis
|December 17, 2019
Summary
Thromboelastography (TEG) can detect hypercoagulability in new-onset Systemic Lupus Erythematosus (SLE) patients. TEG parameters correlate with lupus anticoagulant levels and disease activity, showing its clinical value.
Area of Science:
- Rheumatology
- Hematology
- Clinical Diagnostics
Background:
- Thromboelastography (TEG) assesses coagulation from clot formation to lysis.
- Systemic Lupus Erythematosus (SLE) is associated with coagulation abnormalities.
Purpose of the Study:
- Evaluate TEG's function in detecting coagulation status in new-onset SLE patients.
- Explore correlations between TEG parameters and clinical/laboratory data in SLE.
Main Methods:
- Included 41 treatment-naïve new-onset SLE patients and 56 healthy controls.
- Performed TEG and other laboratory tests.
- Collected clinical data.
Main Results:
- Significant differences in TEG reaction time and clot firmness between SLE patients and controls.
- TEG parameters correlated with lupus anticoagulant levels, platelet count, urinary protein, and SLE disease activity index.
Conclusions:
- TEG shows prospective value in evaluating hypercoagulability in SLE patients.
- TEG can serve as a valuable tool for assessing coagulation in SLE.
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