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Exploration of highly selective fluorogenic 'on-off' chemosensor for H2 PO4 - ions: ICT-based sensing and ATPase
Yogesh B Wagh1, Kundan C Tayade2, Anil Kuwar1
1School of Chemical Sciences, Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon, (MS), India.
Luminescence : the Journal of Biological and Chemical Luminescence
|December 17, 2019
Summary
This study details a new chemosensor (Chemosensor 1) for detecting various anions and bioactive molecules. Its host-receptor signaling mechanism, based on internal charge transfer, was explored for practical applications in biological samples.
Area of Science:
- Analytical Chemistry
- Supramolecular Chemistry
- Computational Chemistry
Background:
- Chemosensors are crucial for detecting specific chemical species.
- Understanding host-receptor interactions is key to designing effective sensors.
- Internal charge transfer (ICT) is a common signaling mechanism in fluorescent sensors.
Purpose of the Study:
- To investigate the recognition capabilities of Chemosensor 1 for anions and bioactive species.
- To explore the host-receptor signaling mechanism of Chemosensor 1.
- To evaluate the practical applicability of Chemosensor 1 in real-world samples.
Main Methods:
- Semiaqueous methanol solution (XH = 0.31) was used for recognition studies.
- Density functional theory (DFT) calculations complemented experimental findings.
- The chemosensor's performance was tested in blood plasma, urine, and tap water.
Main Results:
- Chemosensor 1 demonstrated recognition for a range of anions and bioactive species.
- The internal charge transfer (ICT) mechanism was confirmed as the basis for host-receptor signaling.
- DFT calculations supported the proposed hydrogen bonding interactions for anion coordination.
- The chemosensor showed applicability in analyzing complex biological and environmental samples.
Conclusions:
- Chemosensor 1 is a versatile probe for detecting various analytes.
- The study provides insights into the design principles of ICT-based chemosensors.
- The demonstrated applicability in biological and environmental samples highlights its potential utility.
