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Related Experiment Video

Updated: Jan 1, 2026

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Published on: February 5, 2018

CDH1 on Multigene Panel Testing: Look Before You Leap.

Bryson W Katona¹, Dana Farengo Clark², Susan M Domchek²

¹Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Journal of the National Cancer Institute

|December 17, 2019

Summary

This summary is machine-generated.

Multigene panel testing (MGPT) can reveal unexpected CDH1 gene variants, impacting hereditary diffuse gastric cancer risk assessment. Pretest counseling is crucial for patients and providers navigating these findings.

Area of Science:

Genetics
Oncology
Clinical Diagnostics

Background:

Multigene panel testing (MGPT) is increasingly used for cancer risk assessment.

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Published on: October 20, 2019

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

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Published on: June 21, 2018

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Last Updated: Jan 1, 2026

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

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Published on: February 5, 2018

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

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The CDH1 gene, encoding E-cadherin, is critical for hereditary diffuse gastric cancer (HDGC) syndrome.

Germline CDH1 variants are linked to HDGC, but penetrance in unselected populations may be lower than previously thought.