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Correlation between Helicobacter pylori infection and Crohn's disease: a meta-analysis
1Department of Gastroenterology, Jiaxing Traditional Chinese Medicine Hospital, Jiaxing, China. gracewwl@163.com.
Insights
Helicobacter pylori (Hp) infection appears to be a protective factor against Crohn's disease (CD). Further research is needed to confirm this negative correlation and understand its implications for inflammatory bowel disease pathogenesis.
Area of Science:
- Gastroenterology
- Microbiology
- Immunology
Background:
- The relationship between Helicobacter pylori (Hp) infection and Crohn's disease (CD) remains debated.
- Understanding this association may offer insights into the pathogenesis of inflammatory bowel diseases (IBD).
Purpose of the Study:
- To investigate the correlation between Hp infection and CD susceptibility.
- To provide a theoretical basis for IBD pathogenesis research.
Main Methods:
- A systematic literature review was conducted using Medline, PubMed, and Cochrane databases (1991-2019).
- Data from 20 studies (2055 CD patients, 3442 controls) were analyzed for odds ratio (OR) and 95% confidence interval (CI).
Main Results:
- The prevalence of Hp infection was lower in CD patients (30.6%) compared to controls (42.7%).
- A significant negative correlation was observed between Hp infection and CD [OR=0.42, 95% CI (0.33-0.54), p<0.00001].
- Significant heterogeneity was noted among the included studies.
Conclusions:
- Hp infection may act as a protective factor against the development of Crohn's disease.
- Heterogeneity and potential publication bias warrant caution in interpreting these findings.
- Additional research is essential to elucidate the precise influence of Hp infection on CD.
Objective:
Researches on the potential correlation between Helicobacter pylori (Hp) infection and Crohn's disease (CD) are controversial. This study aims to clarify their correlation and provide a new theoretical basis for uncovering the pathogenesis of inflammatory bowel diseases (IBD).
Materials And Methods:
Relevant literature has been searched reporting the correlation between Hp infection and susceptibility to CD in Medline, PubMed, and Cochrane Collaboration database published from 1991 to 2019. Data of the eligible literature were extracted and analyzed for the OR and the corresponding 95% CI using the Review Manager (RevMan) software.
Results:
A total of 20 pieces of literature involving 2055 cases of CD patients and 3442 cases of controls were enrolled. Hp infection rate in CD patients and controls was 30.6% and 42.7%, respectively. There was a significant difference in Hp infection rate between CD patients and controls [OR=0.42, 95% CI (0.33-0.54), p<0.00001], showing a negative correlation. Heterogeneity existed between the included studies.
Conclusions:
Hp infection is a protective factor for CD. However, heterogeneity and publication bias may restrict the accuracy of the conclusions. It is necessary to further explore the potential influence of the Hp infection on CD.
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