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Tau as a potential therapeutic target for ischemic stroke
1Department of Geriatrics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Aging
|December 17, 2019
Summary
Dysfunctional tau protein contributes to pathological changes after ischemic stroke. This review explores tau
Area of Science:
- Neuroscience
- Neurology
- Pathology
Background:
- Tau protein is primarily expressed in the adult human brain.
- Stroke, particularly ischemic stroke, is a leading cause of death and disability.
- Dysfunctional tau is implicated in the pathology of ischemic stroke, but its precise role requires clarification.
Purpose of the Study:
- To review the structure and biological function of tau protein.
- To summarize the regulatory mechanisms of tau in ischemic stroke.
- To discuss therapeutic strategies for ischemic stroke targeting tau.
Main Methods:
- Literature review of existing studies on tau protein and ischemic stroke.
- Analysis of tau protein's structure, function, and regulatory roles.
- Examination of current therapeutic research findings.
Main Results:
- Tau protein's structure and function are detailed.
- Potential mechanisms linking tau to ischemic stroke pathology are outlined.
- Therapeutic interventions related to tau in stroke are discussed.
Conclusions:
- Understanding tau's role is crucial for ischemic stroke research.
- Further investigation into tau mechanisms may lead to novel therapeutic approaches.
- This review provides a foundation for clinical and experimental studies on tau and stroke.
