Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

7.5K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
7.5K
Thermosensation01:43

Thermosensation

33.5K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
33.5K
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

13.8K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
13.8K
Ion Channels01:19

Ion Channels

90.9K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
90.9K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

3.6K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
3.6K
Non-gated Ion Channels01:24

Non-gated Ion Channels

7.9K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
7.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct roles of MCM2-7 subunits in replication licensing in human cells.

Nature communications·2026
Same author

Deciphering Flavor Characteristics and Brand Differences of Braised Sauce Used for Guilin Rice Noodles.

Journal of food science·2026
Same author

Determining Physical Function Measures for Estimating VO<sub>2</sub>Peak in Patients Receiving Hemodialysis.

Kidney medicine·2026
Same author

A Highly Sensitive Silver Nanostars/Silver Nanoisland Films Hybrid SERS Platform Assisted by a Convolutional Neural Network for Accurate Pesticide Detection.

Journal of agricultural and food chemistry·2026
Same author

Association between glycated hemoglobin levels and changes in aqueous humor inflammatory cytokines during sequential cataract surgeries in patients with type 2 diabetes mellitus: A retrospective study.

Medicine·2026
Same author

Highly Loaded Erlotinib Tubular Micromotor for Targeted Drug Delivery, pH Responsive Release and Ultrasound Tracking: A Three-In-One Micromachine.

Small methods·2026

Related Experiment Video

Updated: Jan 1, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

10.5K

Structural insights into group II TRP channels.

Michael Fine1, Xiaochun Li2, Shangyu Dang3

  • 1Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States.

Cell Calcium
|December 17, 2019
PubMed
Summary

The TRP channel superfamily has two groups: Group I (TRPC/V/M/N/A) and Group II (TRPML, TRPP). Recent structural studies offer molecular insights into Group II TRP channels.

Keywords:
Cryo-EM structureMucolipidosisPKDPolycystinTRPMLTRPP

More Related Videos

Purification of Endogenous Drosophila Transient Receptor Potential Channels
08:39

Purification of Endogenous Drosophila Transient Receptor Potential Channels

Published on: December 28, 2021

2.1K
Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
11:53

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Published on: July 3, 2018

8.3K

Related Experiment Videos

Last Updated: Jan 1, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
12:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

10.5K
Purification of Endogenous Drosophila Transient Receptor Potential Channels
08:39

Purification of Endogenous Drosophila Transient Receptor Potential Channels

Published on: December 28, 2021

2.1K
Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
11:53

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Published on: July 3, 2018

8.3K

Area of Science:

  • Molecular biology
  • Biophysics
  • Structural biology

Background:

  • The Transient Receptor Potential (TRP) channel superfamily comprises seven members, divided into Group I (TRPC, TRPV, TRPM, TRPN, TRPA) and Group II (TRPML, TRPP).
  • Group II TRP channels (TRP MucoLipin and TRP Polycystin) are distinguished by significant sequence homology in their transmembrane domains and a unique large luminal/extracellular domain.

Purpose of the Study:

  • To review and synthesize recent structural and functional data on Group II TRP channels.
  • To provide molecular insights into the TRPML and TRPP channel families.

Main Methods:

  • Compilation and discussion of published research.
  • Analysis of structural data obtained via cryo-electron microscopy (cryo-EM) and X-ray crystallography.
  • Integration of recent functional analyses.

Main Results:

  • Over ten research papers since 2016 have reported diverse structures of Group II TRP channels.
  • These structural studies, complemented by functional analyses, have significantly advanced understanding of TRPML and TRPP channels.

Conclusions:

  • Recent structural and functional studies provide a robust molecular understanding of Group II TRP channels.
  • This review consolidates current knowledge, highlighting key molecular insights into the TRPML and TRPP channel families.