Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hydrofluoric acid-induced hypocalcemia.

R J Greco1, C E Hartford, L R Haith

  • 1Division of Plastic and Reconstructive Surgery, University of Pittsburgh, Pennsylvania.

The Journal of Trauma
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Review of contraception in ungulate species.

Zoo biology·2009
Same author

Massive liposuction in the moderately obese patients: a preliminary study.

Aesthetic surgery journal·2009
Same author

Glucocorticoids of bison bulls in relation to social status.

Hormones and behavior·2005
Same author

Fecal androgens of bison bulls during the rut.

Hormones and behavior·2004
Same author

Identification of a series of C(21)O(2) pregnanes from fecal extracts of a pregnant black rhinoceros (Diceros bicornis minor).

Steroids·2001
Same author

Beware of fire!

Plastic and reconstructive surgery·2001
Same journal

Article.

The Journal of trauma·2014
Same journal

Article.

The Journal of trauma·2014
Same journal

Program schedule for the sixty-fifth annual meeting of the american association for the surgery of trauma.

The Journal of trauma·2014
Same journal

Letters to the editor.

The Journal of trauma·2014
Same journal

Posttraumatic brachial plexitis.

The Journal of trauma·2011
Same journal

Incidental findings in focused assessment with sonography for trauma in hemodynamically stable blunt trauma patients: speaking about cost to benefit.

The Journal of trauma·2011
See all related articles

Hydrofluoric acid exposure can cause lethal calcium depletion. Prompt calcium administration, both intravenous and subcutaneous, successfully treated severe hypocalcemia in two patients, marking a significant advancement in managing fluoride poisoning.

Area of Science:

  • Toxicology
  • Emergency Medicine
  • Biochemistry

Background:

  • Hydrofluoric acid (HF) exposure presents a unique toxicological challenge due to the fluoride ion's affinity for calcium.
  • The severe hypocalcemia induced by HF poisoning can be life-threatening, yet documented cases and successful treatments are scarce.

Observation:

  • Three patients exposed to hydrofluoric acid presented with acute fluoride poisoning.
  • Serum calcium levels in these patients were critically low, measuring 4.1 mg/dL or less.

Findings:

  • Treatment involved aggressive calcium administration via intravenous and subcutaneous routes.
  • This therapeutic approach successfully replenished biologically active calcium and bound circulating fluoride ions.
  • Two of the three patients survived severe hypocalcemia, representing the first reported successful treatments for this condition.

Related Experiment Videos

Implications:

  • This case series highlights the critical importance of prompt and aggressive calcium therapy in managing severe hydrofluoric acid poisoning.
  • The findings suggest a potentially life-saving treatment protocol for acute fluoride-induced hypocalcemia.
  • Further research into optimal calcium dosing and administration for HF exposure is warranted.