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The Influence of Light on Reactive Oxygen Species and NF-кB in Disease Progression

Naresh Kumar Rajendran1, Blassan P George1, Rahul Chandran1

  • 1Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Johannesburg 2028, South Africa.

Antioxidants (Basel, Switzerland)
|December 18, 2019
PubMed

Insights

Reactive oxygen species (ROS) are key signaling molecules with dual roles in health and disease. Understanding ROS regulation by photobiomodulation (PBM) and its crosstalk with NF-κB is crucial for managing conditions like diabetes and cancer.

Area of Science:

  • Biochemistry
  • Cellular Biology
  • Medical Science

Background:

  • Reactive oxygen species (ROS) are critical signaling molecules involved in cellular processes.
  • Elevated ROS levels contribute to oxidative stress, genetic damage, and tumorigenesis.
  • ROS play paradoxical roles, with high levels implicated in diabetes and low levels essential for wound healing.

Purpose of the Study:

  • To explore the multifaceted roles of ROS in cellular signaling and disease.
  • To investigate the therapeutic potential of photobiomodulation (PBM) and photodynamic therapy (PDT) in managing ROS-related conditions.
  • To elucidate the regulatory mechanisms of PBM involving ROS and NF-κB.

Main Methods:

  • Review of literature on ROS, oxidative stress, PBM, and PDT.
  • Analysis of signaling pathways involving ROS and NF-κB.
  • Examination of ROS roles in diabetes, wound healing, and cancer.

Main Results:

  • ROS are vital secondary metabolites with significant roles in cellular signaling.
  • Oxidative stress, driven by ROS, is a hallmark of diabetic conditions.
  • PBM and PDT offer distinct therapeutic strategies by modulating ROS levels.

Conclusions:

  • ROS levels are critical indicators in various cellular contexts.
  • PBM's regulation of ROS and NF-κB crosstalk is vital for managing diverse health conditions.
  • Targeting ROS pathways holds promise for therapeutic interventions in metabolic and oncological diseases.
Keywords:
cancerdiabetesnuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB)photobiomodulationreactive oxygen species (ROS)wound healing

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