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Heart-type fatty acid-binding protein (H-FABP), pentraxin-3 (PTX-3) and thrombomodulin in bovine traumatic

Ramazan Yildiz1, Mahmut Ok2, Merve Ider2

  • 1Department of Internal Medicine, Faculty of Veterinary Medicine, Mehmet Akif Ersoy University, 15030, Burdur, Turkey.

Acta Veterinaria Hungarica
|December 18, 2019
PubMed

Insights

Biomarkers heart-type fatty acid-binding protein (H-FABP), pentraxin-3 (PTX-3), and thrombomodulin (TM) show promise for diagnosing bovine traumatic pericarditis (TP). Elevated levels of these cardiac damage markers aid in detecting TP in cattle.

Area of Science:

  • Veterinary Cardiology
  • Biomarker Discovery
  • Bovine Medicine

Background:

  • Bovine traumatic pericarditis (TP) poses a significant health concern in cattle.
  • Accurate and early diagnosis of TP is crucial for effective treatment and prognosis.
  • Established diagnostic methods for TP can be invasive or lack sensitivity.

Purpose of the Study:

  • To evaluate heart-type fatty acid-binding protein (H-FABP), pentraxin-3 (PTX-3), and thrombomodulin (TM) as biomarkers for bovine traumatic pericarditis (TP).
  • To assess the utility of these biomarkers in the detection and prognosis of TP in Holstein cows.
  • To compare serum levels of H-FABP, PTX-3, and TM between cows with TP and healthy controls.

Main Methods:

  • Diagnosis of spontaneous TP based on clinical signs, blood counts, glutaraldehyde test, ultrasonography, and pericardiocentesis.
  • Serum samples from 25 Holstein cows with TP and 10 healthy controls were analyzed.
  • Bovine-specific ELISA kits were used to measure serum concentrations of H-FABP, PTX-3, and TM.

Main Results:

  • Serum H-FABP levels were significantly higher in cows with TP compared to controls (P < 0.05).
  • Elevated serum PTX-3 and TM levels were also observed in cows with TP (P < 0.05).
  • H-FABP showed positive correlations with cardiac troponin-I, CK-MB, PTX-3, and TM, indicating cardiac damage.

Conclusions:

  • H-FABP, PTX-3, and TM are significantly elevated in bovine traumatic pericarditis.
  • These cardiac damage biomarkers demonstrate potential for the diagnosis of TP in cattle.
  • Further research can explore their role in predicting the prognosis of bovine TP.

Keywords:
Biomarkerheart-type fatty acid-binding protein (H-FABP)pentraxin-3 (PTX-3)thrombomodulintraumatic pericarditis

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