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Related Experiment Video

Updated: Jan 1, 2026

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

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Does Diffuse Axonal Injury MRI Grade Really Correlate with Functional Outcome?

Subash Lohani1, Shreeram Bhandari1, Kajan Ranabhat2

  • 1Department of Neurosurgery, Upendra Devkota Memorial National Institute for Neurological and Allied Sciences, Bansbari, Kathmandu, Nepal.

World Neurosurgery
|December 18, 2019
PubMed
Summary
This summary is machine-generated.

Glasgow Coma Scale (GCS) at admission predicts outcomes better than diffuse axonal injury (DAI) grade. Higher DAI grades did not correlate with unfavorable outcomes in this study.

Keywords:
DAIGOSE

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Area of Science:

  • Neuroscience
  • Trauma Surgery
  • Radiology

Background:

  • Diffuse axonal injury (DAI) is a primary traumatic brain injury.
  • Assessing DAI severity and predicting patient outcomes are critical clinical challenges.

Purpose of the Study:

  • To investigate the association between diffuse axonal injury (DAI) grades and the extended Glasgow Outcome Scale (GOSE).
  • To determine predictors of outcome following DAI.

Main Methods:

  • Retrospective review of 40 patients diagnosed with DAI.
  • Data collected included age, sex, Glasgow Coma Scale (GCS) on admission, DAI grade, hospital stay, and seizures.
  • Extended Glasgow Outcome Scale (GOSE) assessed at 6 months post-discharge.

Main Results:

  • Mean GCS on admission was 9.67; mean GOSE at 6 months was 6.10.
  • Higher DAI grades (I, II, III) were not significantly associated with unfavorable outcomes.
  • Lower GCS scores at admission correlated with significantly poorer outcomes.

Conclusions:

  • Glasgow Coma Scale (GCS) on admission is a more reliable predictor of outcome than DAI grade.
  • Clinical assessment of initial neurological status is crucial for DAI prognosis.