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Updated: Jan 1, 2026

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
Published on: June 4, 2020
Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation
G Torromino1, L Autore1, V Khalil1
1Department of Biology and Biotechnology 'C. Darwin', Center for Research in Neurobiology 'D. Bovet', Sapienza University of Rome, Rome, Italy.
Abstract:
The hippocampal formation is considered essential for spatial navigation. In particular, subicular projections have been suggested to carry spatial information from the hippocampus to the ventral striatum. However, possible cross-structural communication between these two brain regions in memory formation has thus far been unknown. By selectively silencing the subiculum-ventral striatum pathway we found that its activity after learning is crucial for spatial memory consolidation and learning-induced plasticity. These results provide new insight into the neural circuits underlying memory consolidation and establish a critical role for off-line cross-regional communication between hippocampus and ventral striatum to promote the storage of complex information.
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