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Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation
G Torromino1, L Autore1, V Khalil1
1Department of Biology and Biotechnology 'C. Darwin', Center for Research in Neurobiology 'D. Bovet', Sapienza University of Rome, Rome, Italy.
Nature Communications
|December 18, 2019
Summary
Activity in the subiculum-ventral striatum pathway after learning is crucial for spatial memory consolidation. This pathway
Area of Science:
- Neuroscience
- Cognitive Science
- Memory Research
Background:
- The hippocampal formation is vital for spatial navigation.
- Subicular projections are hypothesized to transmit spatial information from the hippocampus to the ventral striatum.
- The role of cross-structural communication between these regions in memory formation was previously unknown.
Purpose of the Study:
- To investigate the role of the subiculum-ventral striatum pathway in memory consolidation.
- To determine if communication between the hippocampus and ventral striatum is essential for spatial memory storage.
Main Methods:
- Selective silencing of the subiculum-ventral striatum pathway in a learning paradigm.
- Assessment of spatial memory consolidation and learning-induced plasticity.
Main Results:
- Silencing the subiculum-ventral striatum pathway after learning impaired spatial memory consolidation.
- Pathway activity was found to be critical for learning-induced plasticity.
- This highlights the importance of off-line communication between brain regions.
Conclusions:
- The subiculum-ventral striatum pathway plays a critical role in spatial memory consolidation.
- Off-line communication between the hippocampus and ventral striatum is essential for storing complex information.
- This provides new insights into the neural circuits governing memory.
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