Iron requirements in the first 2 years of life

Sharon L Unger1, Tanis R Fenton1, Radha Jetty1

  • 1Canadian Paediatric Society, Nutrition and Gastroenterology Committee, Ottawa, Ontario.

Paediatrics & Child Health
|December 18, 2019
PubMed

Insights

Ensuring adequate iron intake in early childhood is crucial for healthy development and preventing neurodevelopmental issues. Both iron deficiency and excess pose risks during the critical first two years of life.

Area of Science:

  • Pediatric Nutrition
  • Developmental Biology
  • Micronutrient Metabolism

Background:

  • Iron is vital for hemoglobin synthesis, neurological development, and immune function.
  • Early childhood iron deficiency is linked to impaired neurodevelopment.
  • Risk factors include low socioeconomic status, preterm birth, and poor diet.

Purpose of the Study:

  • To highlight the critical importance of appropriate iron intake in the first two years of life.
  • To emphasize the vulnerability of early childhood to iron deficiency.
  • To acknowledge the potential risks of iron excess due to the lack of an excretory mechanism.

Main Methods:

  • Literature review on iron metabolism in early childhood.
  • Analysis of risk factors associated with iron deficiency.
  • Examination of the consequences of both iron deficiency and excess.

Main Results:

  • Iron deficiency in early childhood can lead to irreversible neurodevelopmental impairments.
  • Suboptimal diets and socioeconomic factors significantly increase deficiency risk.
  • The human body lacks an efficient iron excretion pathway, increasing overload risk.

Conclusions:

  • Appropriate iron supplementation and dietary intake are critical for infants and toddlers.
  • Monitoring iron status is essential to prevent both deficiency and toxicity.
  • Further research into optimal iron management strategies for early childhood is warranted.

Related Concept Videos

Lifecycle of Erythrocytes01:22

Lifecycle of Erythrocytes

Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups....
4.5K
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
713
Erythropoiesis01:14

Erythropoiesis

Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
5.6K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
8.0K
Minerals01:26

Minerals

Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
 
Major...
1.0K
Factors Affecting Erythropoiesis01:24

Factors Affecting Erythropoiesis

The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
Several factors influence the erythrocyte production rate, with tissue oxygen level being among the most critical. Intense exercise or high altitudes can cause tissue hypoxia, which triggers the kidneys to release more erythropoietin (EPO) into the bloodstream.
EPO then...
5.3K