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Blinding

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.

Blind Procedures

Blind Procedures

Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...

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Related Experiment Video

Updated: Jan 1, 2026

Comparison of Three Clinical Stereoscopic Methods for Measuring Binocular Visual Function During Amblyopic Treatment in Unilateral Amblyopia

Comparison of Three Clinical Stereoscopic Methods for Measuring Binocular Visual Function During Amblyopic Treatment in Unilateral Amblyopia

Published on: September 27, 2024

Comparison between patching and interactive binocular treatment in amblyopia: A randomized clinical trial.

Zhale Rajavi^1,2,3, Hamideh Sabbaghi^4,5, Ebrahim Amini Sharifi⁶

¹Ophthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Journal of Current Ophthalmology

|December 18, 2019

Summary

Interactive binocular treatment (I-BiT™) and standard patching showed similar improvements in amblyopic children's visual acuity after one month. Further research is needed to assess long-term effectiveness and recurrence.

Keywords:

Amblyopia I-BiT™Interactive binocular treatment Patch therapy

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Last Updated: Jan 1, 2026

Comparison of Three Clinical Stereoscopic Methods for Measuring Binocular Visual Function During Amblyopic Treatment in Unilateral Amblyopia

Comparison of Three Clinical Stereoscopic Methods for Measuring Binocular Visual Function During Amblyopic Treatment in Unilateral Amblyopia

Published on: September 27, 2024

Stereoacuity Improvement using Random-Dot Video Games

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Published on: January 14, 2020

The Measurement and Treatment of Suppression in Amblyopia

The Measurement and Treatment of Suppression in Amblyopia

Published on: December 14, 2012

Area of Science:

Ophthalmology
Pediatric Medicine
Vision Science

Background:

Amblyopia, or "lazy eye," affects visual development in children.
Current treatments often involve patching the stronger eye to encourage the weaker eye's development.
Novel therapeutic approaches aim to improve treatment efficacy and patient compliance.

Purpose of the Study:

To compare the effectiveness of interactive binocular treatment (I-BiT™) versus standard patching for amblyopia.
To evaluate visual acuity and stereopsis changes in children undergoing these treatments.

Main Methods:

A randomized clinical trial involving 38 children (3-10 years old) with unilateral amblyopia.
Participants received either I-BiT™ games or standard patching with a placebo I-BiT™ game for one month.
Best-corrected visual acuity (BCVA) and stereopsis were assessed at baseline and after treatment.

Main Results:

Both I-BiT™ and standard patching led to significant improvements in BCVA (P < 0.001).
No significant difference in BCVA improvement was found between the two groups (P = 0.52).
Stereopsis improved in both groups, but without significant inter-group differences.

Conclusions:

I-BiT™ and standard patching demonstrate comparable BCVA improvements in amblyopic children after one month.
Further randomized clinical trials with larger sample sizes and longer durations are recommended.
Future studies should also assess the recurrence of amblyopia after treatment.