Impact of temperature changes between neighboring days on COPD in a city in Northeast China

Sudden temperature changes between neighboring days (T_24h) have adverse effects on human health. In this study, we used a time series analysis to evaluate the impact of T_24h on the number of hospital admissions for chronic obstructive pulmonary disease (COPD) from 2009 to 2012 in Changchun (the capital of Northeast China's Jilin province). We performed the analysis in a generalized additive model (GAM), and the controlling factors included long-term trends, day of the week effect, and the selected weather elements. We divided the entire study group into two gender subgroups (males and females) and two age subgroups (aged < 65 years and aged ≥ 65 years). T_24h showed the greatest effect on the entire study group at lag 3 days. In particular, the greatest effect of T_24h on females (males) occurred at lag 1 day (lag 3 days); the greatest effect of T_24h on the aged ≥ 65 years (aged < 65 years) occurred at lag 1 day (lag 6 days). This indicates that temperature changes between neighboring days have a relatively more acute effect on the elderly and the females than on the younger people and the males. When T_24h is less than zero, the highest RR of the number of hospital admissions for COPD occurred at lag 4 days during the warm season (1.025, 95% CI: 0.981, 1.069) and lag 3 days during the cold season (1.019, 95% CI: 0.988, 1.051). When T_24h is greater than zero, the highest RR of the number of hospital admissions for COPD occurred at lag 6 days during the warm season (1.026, 95% CI: 0.977, 1.077) and lag 5 days during the cold season (1.021, 95% CI: 0.986, 1.057). The results of this study could be provided to local health authorities as scientific guidelines for controlling and preventing COPD in Changchun, China.