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Cardiac changes associated with vascular aging

Narayana Sarma V Singam1, Christopher Fine1, Jerome L Fleg2

  • 1Division of Cardiovascular Medicine, University of Louisville, Louisville, Kentucky.

Clinical Cardiology
|December 18, 2019
PubMed

Insights

Cardiovascular aging involves arterial stiffening and heart remodeling, increasing risks for ischemia and heart failure, especially with comorbidities. Understanding these changes is key to developing interventions.

Area of Science:

  • Gerontology
  • Cardiovascular Physiology
  • Internal Medicine

Background:

  • Cardiovascular aging is characterized by structural and functional changes in the heart and vasculature.
  • Arterial stiffening leads to increased blood pressure and cardiac workload.
  • Myocardial remodeling occurs to compensate for vascular changes.

Purpose of the Study:

  • To review the pathophysiology of cardiovascular aging.
  • To discuss therapeutic interventions for age-related cardiovascular changes.

Main Methods:

  • Literature review of cardiovascular aging.
  • Analysis of adaptive and maladaptive changes in the aging cardiovascular system.

Main Results:

  • Aging arteries thicken and lose compliance, increasing pulse wave velocity and systolic blood pressure.
  • The myocardium remodels to maintain function but becomes more susceptible to ischemia and heart failure.
  • Age-associated comorbidities exacerbate cardiovascular aging effects.

Conclusions:

  • Cardiovascular aging involves complex adaptive changes that increase vulnerability to heart disease.
  • Therapeutic strategies targeting these aging processes are crucial for maintaining cardiovascular health in older adults.

Keywords:
aging and the cardiovascular systemcardiac mechanicsechocardiographyheart failureremodeling

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