Manual vs automated ⁶⁸ Ga-radiolabelling-A comparison of optimized processes

A critical factor for clinical practice is the production of ⁶⁸ Ga radiopharmaceuticals manufactured manually or through an automated procedure. ⁶⁸ Ga radiopharmaceuticals are often prepared manually, although this method can lead to an increased operator's radiation dose and potential variability within production. The present work compares ⁶⁸ Ga-radiolabelling (PSMA-11; DOTA-TOC) utilizing a cassette module (GAIA; Elysia-Raytest; Germany) with a manual setup for routine clinical production with regard to process reliability and reproducibility.