Related Experiment Video
Updated: Jan 1, 2026
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
16.6K
Test-Retest Reliability for Physical Function Measures in Patients with Chronic Kidney Disease
Ioulia Hadjiioannou1, Katy Wong1, Herolin Lindup2
1Physiotherapy, Department of Physiotherapy, School of Bioscience Education, King's College London, London, UK.
Journal of Renal Care
|December 18, 2019
Summary
This study found good test-retest reliability for key physical and mental health measures in chronic kidney disease (CKD) patients. These findings help clinicians track true patient improvements using tests like the incremental shuttle walk test (ISWT) and hospital anxiety and depression scale (HAD).
Area of Science:
- Nephrology
- Rehabilitation Medicine
- Clinical Measurement
Background:
- Reliability of outcome measures is crucial for assessing true changes in chronic kidney disease (CKD) patients undergoing exercise interventions.
- Establishing relative and absolute reliability values helps differentiate genuine patient progress from measurement error.
Purpose of the Study:
- To evaluate the test-retest reliability of the incremental shuttle walk test (ISWT), 60-second sit-to-stand (STS-60), timed up and go (TUAG), Duke's activity status index (DASI), and hospital anxiety and depression scale (HAD) in CKD patients.
- To provide essential data for the clinical application of these frequently used outcome measures in CKD care.
Main Methods:
- A pragmatic, non-randomized controlled trial design was employed.
- Forty CKD patients completed two assessment visits within a 16-day interval.
- Relative reliability was determined using intraclass correlation coefficients (ICC), while absolute reliability was assessed via standard error of measurement (SEM) and minimal detectable change (MDC) at a 90% confidence interval.
Main Results:
- All tested outcome measures demonstrated good test-retest reliability across the CKD patient sample.
- The timed up and go (TUAG) test exhibited the highest reliability (ICC = 0.96), while the hospital anxiety and depression scale (HAD) showed the lowest (ICC = 0.71).
- Key minimal detectable change (MDC) values at 90% CI were: ISWT 79.6m, TUAG 2.9s, STS-60 7.0 repetitions, DASI 8.4, HAD-Anxiety 3.8, and HAD-Depression 4.4.
Conclusions:
- The study confirms good test-retest reliability for multiple outcome measures throughout the CKD patient journey.
- While reliability is generally good, careful interpretation is advised for specific CKD sub-groups.
- The calculated MDC scores provide valuable benchmarks for clinicians to identify true improvements in CKD patients' physical and psychological status.
More Related Videos
Related Concept Videos
01:24Serum Studies: Renal Function Tests
319
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
319
01:28Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
140
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
140
01:28Chronic Kidney Disease III: Interprofessional Care
298
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
298
01:29Acute Kidney Injury III: Clinical Manifestations
718
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
718
01:17Factors Affecting Renal Clearance: Renal Impairment
375
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
375
01:25Chronic Kidney Disease I: Introduction
509
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
509