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Cross-linking treatment for better visual acuity.

Senad Grišević1, Fanka Gilevska2, Alma Biščević3,4

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Medicinski Glasnik : Official Publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
|December 18, 2019
PubMed
Summary

Corneal cross-linking (CXL) improves vision in keratoconus patients within a year. While Kmax changes weren't immediately linked to vision gains, CXL offers both stabilization and visual acuity enhancement.

Keywords:
corneal stromakeratoconusrefractive errorstomography

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Vision Science

Background:

  • Keratoconus is a progressive corneal disease affecting visual acuity.
  • Corneal cross-linking (CXL) is a standard treatment to halt keratoconus progression.
  • The impact of CXL on visual acuity and specific topographical parameters requires further elucidation.

Purpose of the Study:

  • To investigate the correlation between changes in maximum anterior sagittal curvature (Kmax) and visual acuity outcomes post-CXL.
  • To assess the longitudinal changes in Kmax, uncorrected distance visual acuity (UDVA), and corrected distance visual acuity (CDVA) after CXL.

Main Methods:

  • Analysis of 44 eyes from 34 keratoconus patients undergoing standard Dresden protocol CXL.
  • 12-month follow-up including visual acuity testing (UDVA, CDVA) and Oculus Pentacam analysis.
  • Correlation analysis of Kmax changes with visual acuity outcomes at 6 and 12 months post-procedure.

Main Results:

  • Significant visual acuity improvement observed within 3 months, with further gains by 12 months post-CXL.
  • Kmax showed significant changes at 12 months but not within the first 6 months.
  • No direct correlation was found between Kmax reduction and visual acuity improvement in the initial 6 months.

Conclusions:

  • Corneal CXL is effective in improving visual acuity in keratoconus patients.
  • CXL provides both corneal stabilization and significant visual rehabilitation.
  • Visual acuity improvements may occur independently of early Kmax topographical changes.