Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

8.9K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
8.9K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

3.2K
3.2K
Genomic DNA in Prokaryotes00:46

Genomic DNA in Prokaryotes

48.0K
The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
Genomic Diversity in Bacteria
Although bacterial genomes are much...
48.0K
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

519
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
519
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

7.9K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
7.9K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

1.0K
Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantifying patient- and hospital-level antimicrobial resistance dynamics in <i>Staphylococcus aureus</i> from routinely collected data.

Journal of medical microbiology·2023
Same author

Markers of epidemiological success of methicillin-resistant Staphylococcus aureus isolates in European populations.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2023
Same author

Quantifying patient- and hospital-level antimicrobial resistance dynamics in <i>Staphylococcus aureus</i> from routinely collected data.

medRxiv : the preprint server for health sciences·2023
Same author

Correction for Leclerc et al., "Growth-Dependent Predation and Generalized Transduction of Antimicrobial Resistance by Bacteriophage".

mSystems·2022
Same author

Modelling the synergistic effect of bacteriophage and antibiotics on bacteria: Killers and drivers of resistance evolution.

PLoS computational biology·2022
Same author

Growth-Dependent Predation and Generalized Transduction of Antimicrobial Resistance by Bacteriophage.

mSystems·2022
Same journal

Morphotype-specific susceptibility to <i>Neosartorya</i> (<i>Aspergillus</i>) <i>fischeri</i> antifungal protein 2 is associated with an anabolic transcriptional signature in <i>Candida</i>.

Microbiology spectrum·2026
Same journal

High abundance of <i>Stenotrophomonas maltophilia</i> in slaty-backed gull breeding in Northern Japan.

Microbiology spectrum·2026
Same journal

Rhein reduces conjugation of IncFII-type plasmids in <i>Escherichia coli</i> and mitigates the spread of antibiotic resistance genes.

Microbiology spectrum·2026
Same journal

Phenotypic discordance in rifampicin resistance detection among <i>Mycobacterium tuberculosis</i> isolates from China: insights from whole-genome sequencing and a structured literature review.

Microbiology spectrum·2026
Same journal

Identification of protein secretion systems and type III effectors in wood-associated bacteria of the genus <i>Xylophilus</i>.

Microbiology spectrum·2026
Same journal

Intraspecific diversity of <i>Staphylococcus aureus</i> populations isolated from cystic fibrosis respiratory infections.

Microbiology spectrum·2026
See all related articles

Related Experiment Video

Updated: Jan 1, 2026

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
07:10

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues

Published on: February 19, 2019

9.4K

Staphylococci: Evolving Genomes.

Jodi A Lindsay1

  • 1St. George's, University of London, Institute of Infection and Immunity, London, United Kingdom.

Microbiology Spectrum
|December 18, 2019
PubMed
Summary
This summary is machine-generated.

Staphylococcus aureus (S. aureus) genome analysis reveals how this pathogen adapts and evolves. Understanding these bacterial genomes helps identify mechanisms driving antibiotic resistance and host adaptation.

More Related Videos

Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus
10:39

Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus

Published on: March 10, 2017

17.2K
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.7K

Related Experiment Videos

Last Updated: Jan 1, 2026

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues
07:10

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues

Published on: February 19, 2019

9.4K
Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus
10:39

Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus

Published on: March 10, 2017

17.2K
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.7K

Area of Science:

  • Genomics
  • Microbiology
  • Pathogen Evolution

Background:

  • Staphylococci, particularly Staphylococcus aureus, are significant causes of diverse infections across various hosts.
  • Whole-genome sequencing has revolutionized the study of bacterial genomes, providing vast amounts of data on S. aureus.

Purpose of the Study:

  • To analyze staphylococcal genomes to understand the biology, pathobiology, and dissemination mechanisms of S. aureus.
  • To explore the evolutionary adaptations and genetic variations that contribute to the success of S. aureus as a pathogen.

Main Methods:

  • Comprehensive analysis of large-scale genomic data from S. aureus strains.
  • Comparative genomics to identify variations between different strains.
  • Investigation of genetic variation mechanisms and their impact on pathogen traits.

Main Results:

  • Genomic insights are clarifying the selective pressures faced by staphylococci in different environments.
  • Mechanisms enabling S. aureus adaptation, survival, and spread are becoming evident.
  • Constant genome alteration, DNA exchange, and adaptation drive the emergence of successful, resistant, and host-adapted strains.

Conclusions:

  • The study highlights the dynamic evolution of staphylococci, driven by genomic changes.
  • Understanding these evolutionary processes is crucial for combating antibiotic resistance and S. aureus infections.
  • Features of successful S. aureus clones are elucidated through genomic analysis.