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Immunomodulating effect of neurotropin on delayed type hypersensitivity response in mice
H Yoshii1, T Matsuoka, Y Kurimoto
1Department of Immunology and Allergy, Nippon Zoki Pharmaceutical Company, Hyogo, Japan.
Japanese Journal of Pharmacology
|August 1, 1988
Abstract:
Effect of Neurotropin on the delayed type hypersensitivity (DTH) response to sheep red blood cells was examined in mice. Neurotropin suppressed the high DTH responses in ddY and BALB/c mice, while it enhanced the low DTH response in C57BL/6 mice when administered after sensitization. In addition, Neurotropin exerted a suppressive effect on the enhanced DTH response by cyclophosphamide pretreatment in C57BL/6 mice, but had a restorative effect on the suppressed DTH response in ddY mice loaded with restraint stress.