Related Experiment Video
Updated: Jan 1, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
Hypertensive Urgency and Emergency in Alcohol Withdrawal: A Literature Review
Ermal Bojdani1,2,3,4, Anderson Chen2,3,4, Tina Zhang5
1Harvard South Shore Psychiatry Residency Training Program, 940 Belmont St, Brockton, MA 02301. Bojdani2@gmail.com.
Insights
Hypertension can occur during alcohol detoxification, potentially leading to hypertensive urgency or emergency. Clinicians should monitor blood pressure and individualize treatment, considering patient comorbidities and potential end-organ damage.
Area of Science:
- Internal Medicine
- Cardiology
- Addiction Medicine
Background:
- Alcohol withdrawal syndrome (AWS) can manifest with significant physiological changes.
- Hypertension is a common, though often transient, finding during AWS.
- The risk of hypertensive urgency and emergency in AWS patients necessitates clinical vigilance.
Purpose of the Study:
- To inform clinicians about the potential for hypertension, hypertensive urgency, and hypertensive emergency in patients undergoing alcohol detoxification.
- To review diagnostic and treatment strategies for managing blood pressure in this specific patient population.
Main Methods:
- A comprehensive literature search was conducted on PubMed using terms related to alcohol withdrawal and hypertension.
- Studies were screened for relevance, with a focus on recent publications, and supplemented by expert-reviewed articles.
- Searches for specific terms related to hypertensive urgency/emergency and treatment-resistant hypertension in AWS yielded limited results.
Main Results:
- Hypertension during AWS is generally self-limiting but requires management to prevent severe complications.
- Limited data exists on optimal hypertension management in AWS patients, often requiring individualized approaches.
- Patients with pre-existing treatment-resistant hypertension may experience more challenging blood pressure control during withdrawal.
Conclusions:
- Treatment for hypertension in AWS involves selecting medications based on side effect profiles and patient comorbidities.
- Patients with suspected hypertensive urgency or emergency require thorough medical evaluation to assess for end-organ damage.
Objective:
To help clinicians recognize that hypertension, hypertensive urgency, and hypertensive emergency can arise in patients detoxifying from alcohol. Diagnostic and treatment implications are reviewed to help clinicians manage blood pressure in these situations.
Data Sources:
PubMed was searched with no restrictions on publication date or study type in June 2019 using the terms (alcohol withdrawal) AND hypertension.
Study Selection:
Of 531 studies retrieved, all were reviewed, and articles older than 20 years were excluded. Of the remaining 158 articles, all were reviewed by full-text reading, and 17 were selected based on relevance. Seven UpToDate articles and 2 older papers were also included for relevance.
Data Extraction:
Various other searches were also performed; however, no relevant hits resulted when the following terms were entered: (hypertensive urgency/emergency) AND alcohol withdrawal OR detoxification; (hypertensive urgency/emergency) AND (alcohol withdrawal OR detoxification) AND treatment-resistant hypertension.
Results:
Hypertension is typically self-limited in alcohol withdrawal syndrome; however, treatment is important to prevent hypertensive urgency or emergency. There is a paucity of data on how best to manage hypertension in patients withdrawing from alcohol, with treatment often individualized. Patients with underlying treatment-resistant hypertension may have more difficult-to-control blood pressure, especially in the first 24 hours of withdrawal.
Conclusions:
Multiple medications may be used to treat hypertension in the setting of alcohol withdrawal, with selection based on side effect profile and the patient's other comorbidities. In patients for whom there is concern for hypertensive urgency versus emergency, full medical evaluation is indicated to identify any potential end-organ damage.
More Related Videos
Related Concept Videos
CNS Depressants: Alcohol and Nicotine
Hypertension I: Introduction
Hypertension III: Clinical Manifestations and Diagnostic Studies
Alterations in Blood Pressure
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
Blood Pressure Imbalances and Circulatory Shock
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Hypertension and Regulation of Blood Pressure

