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Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
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Factor VIII replacement is still the standard of care in haemophilia A

Louis Aledort1, Pier Mannuccio Mannucci2, Wolfgang Schramm3

  • 1Division of Hematology/Oncology, Icahn School of Medicine, Mount Sinai, New York, NY, United States of America.

Blood Transfusion = Trasfusione Del Sangue
|December 18, 2019
PubMed

Prophylactic factor VIII (FVIII) has dramatically improved haemophilia A treatment, preventing joint bleeding and halting the deterioration of joint status. FVIII products with an extended plasma half-life further improve patients' quality of life and increase therapeutic adherence. New licensed classes of non-replacement products include prophylactic emicizumab, which is administered subcutaneously up to every 4 weeks. However, this drug is not suitable for acute bleeding episodes or management of major surgery, and long-term data on the impact of emicizumab on joint health, FVIII inhibitor development and thrombotic risk are awaited. Prophylaxis with FVIII replacement remains the standard of care in haemophilia A, with the aim of achieving a level of haemostasis control that allows patients to meet their lifestyle goals.

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