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Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...

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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Particle engineered mannitol for carrier-based inhalation - A serious alternative?

Nancy Hertel¹, Gudrun Birk², Regina Scherließ¹

¹Department of Pharmaceutics and Biopharmaceutics, Kiel University, Grasweg 9a, 24118 Kiel, Germany.

International Journal of Pharmaceutics

|December 18, 2019

Summary

Particle engineered mannitol shows promise as a dry powder inhalation (DPI) carrier, matching or exceeding lactose performance. Mannitol blends offer uniform dosing and comparable or improved respirable fractions for active pharmaceutical ingredients (APIs).

Keywords:

Aerodynamic performance Alpha-lactose (PubChem CID: 84571)Budesonide (PubChem CID: 5281004)Dry powder inhalation Lactose Mannitol (PubChem CID: 6251)Physico-chemical characterisation Salbutamol sulphate (PubChem CID: 39859)

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Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

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Intratracheal Administration of Dry Powder Formulation in Mice

Intratracheal Administration of Dry Powder Formulation in Mice

Published on: July 25, 2020

Area of Science:

Pharmaceutical Technology
Drug Delivery Systems
Materials Science

Background:

Dry powder inhalation (DPI) formulations commonly use lactose as a carrier for micronized active pharmaceutical ingredients (APIs).
Research into alternative DPI carriers has been ongoing, but few have reached the market.

Purpose of the Study:

To evaluate spray-granulated mannitol as a potential alternative carrier for DPI formulations.
To compare the performance of mannitol-based blends against traditional lactose carriers.

Main Methods:

Preparation of DPI blends with varying concentrations (0.1-4%) of two different APIs using lactose and spray-granulated mannitol carriers.
Characterization of physical properties (particle size, morphology, density, flowability) and dosing behavior.
Aerodynamic performance assessment using two inhaler devices and varying flow rates.

Main Results:

Mannitol blends demonstrated good flowability, enabling uniform dosing across API concentrations.
Linear dose delivery was observed with increasing API concentrations.
Respirable fractions for mannitol blends were comparable to lactose for salbutamol sulphate and higher for budesonide.

Conclusions:

Particle-engineered mannitol is a viable alternative carrier for DPI formulations.
Mannitol carriers support consistent dosing and efficient drug delivery, comparable or superior to lactose.