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The Correlation of Central Serous Chorioretinopathy and Subsequent Cardiovascular Diseases of Different Types: A

Hung-Jui Hsu1,2, Chia-Yi Lee2,3, Shih-Chun Chao2,4,5

  • 1Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.

International Journal of Environmental Research and Public Health
|December 19, 2019
PubMed

Insights

Central serous chorioretinopathy (CSC) is linked to increased chronic cardiovascular disease (CVD) risk in middle-aged men. This study found no overall CVD link but identified a specific subgroup risk.

Area of Science:

  • Ophthalmology
  • Cardiology
  • Epidemiology

Background:

  • Central serous chorioretinopathy (CSC) is a condition affecting vision.
  • Cardiovascular diseases (CVDs) represent a significant global health burden.
  • Understanding potential links between ocular and systemic conditions is crucial for comprehensive patient care.

Purpose of the Study:

  • To investigate the association between central serous chorioretinopathy (CSC) and the incidence of cardiovascular diseases (CVDs).
  • To analyze CVD risk across different severities and types in patients with CSC.
  • To identify specific demographic subgroups at higher risk for CVD following CSC diagnosis.

Main Methods:

  • A retrospective cohort study utilizing the National Health Insurance Research Database.
  • Enrolled 2865 patients diagnosed with CSC and 17,460 age- and gender-matched controls (1:4 ratio).
  • Employed Cox proportional hazard regression to calculate adjusted hazard ratios (aHR) for CVD development post-CSC.

Main Results:

  • No significant overall difference in acute or chronic CVD incidence was observed between CSC patients and controls.
  • Subgroup analysis revealed a significantly higher risk of CVD development in males aged 40-59 (aHR: 1.351).
  • This increased risk in middle-aged males was primarily driven by a higher incidence of mild CVD (aHR: 1.391).

Conclusions:

  • Central serous chorioretinopathy (CSC) is associated with an elevated risk of chronic cardiovascular disease (CVD) in middle-aged men.
  • No significant association was found in the female population across all age groups.
  • The findings highlight the importance of considering cardiovascular health in specific male demographics with CSC.

Keywords:
atherosclerosiscardiovascular diseasecentral serous chorioretinopathyepidemiologyseverity

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