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The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium

Ng Desi1, Yvonne Tay1,2

  • 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.

Cells
|December 19, 2019
PubMed

Insights

Post-transcriptional regulation fine-tunes gene expression. Alterations in RNA processing and function can significantly impact the transcriptomic landscape, potentially driving cancer development.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Post-transcriptional regulation is crucial for controlling gene expression.
  • Disruptions in transcriptomic balance are linked to disease, notably cancer.
  • Emerging research highlights coordinated post-transcriptional processes governing RNA molecules.

Purpose of the Study:

  • To review current research on post-transcriptional regulation mechanisms.
  • To explore how RNA processing and function alterations impact gene expression.
  • To elucidate the role of these changes in cancer development.

Main Methods:

  • Literature review of recent studies on post-transcriptional regulation.
  • Analysis of mechanisms affecting RNA processing and function.
  • Synthesis of findings on the transcriptomic consequences in cancer.

Main Results:

  • Small changes in RNA processing can significantly alter the transcriptomic landscape.
  • These alterations can reshape gene expression patterns.
  • The impact of these changes on cancer development is a key focus.

Conclusions:

  • Post-transcriptional regulation is a critical determinant of cellular function.
  • Dysregulation of these processes contributes to oncogenesis.
  • Understanding these mechanisms offers potential therapeutic targets for cancer.
Keywords:
RNA alterationRNA-binding proteincancercompeting endogenous RNAmicroRNApost-transcriptional regulationtranscriptomic equilibrium

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