The Butterfly Effect of RNA Alterations on Transcriptomic Equilibrium
Ng Desi1, Yvonne Tay1,2
1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Cells
|December 19, 2019
Summary
Post-transcriptional regulation fine-tunes gene expression. Alterations in RNA processing and function can significantly impact the transcriptomic landscape, potentially driving cancer development.
Area of Science:
- Molecular Biology
- Genetics
- Cancer Research
Background:
- Post-transcriptional regulation is crucial for controlling gene expression.
- Disruptions in transcriptomic balance are linked to disease, notably cancer.
- Emerging research highlights coordinated post-transcriptional processes governing RNA molecules.
Purpose of the Study:
- To review current research on post-transcriptional regulation mechanisms.
- To explore how RNA processing and function alterations impact gene expression.
- To elucidate the role of these changes in cancer development.
Main Methods:
- Literature review of recent studies on post-transcriptional regulation.
- Analysis of mechanisms affecting RNA processing and function.
- Synthesis of findings on the transcriptomic consequences in cancer.
Main Results:
- Small changes in RNA processing can significantly alter the transcriptomic landscape.
- These alterations can reshape gene expression patterns.
- The impact of these changes on cancer development is a key focus.
Conclusions:
- Post-transcriptional regulation is a critical determinant of cellular function.
- Dysregulation of these processes contributes to oncogenesis.
- Understanding these mechanisms offers potential therapeutic targets for cancer.
Keywords:
RNA alterationRNA-binding proteincancercompeting endogenous RNAmicroRNApost-transcriptional regulationtranscriptomic equilibriumMore Related Videos
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