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[Oxygen--concentration and acid-base status of arterial blood as limiting factors in hemodilution]
1Physiologisches Institut der Universität Mainz.
Normovolemic hemodilution under normoxic conditions (arterial oxygen partial pressure normal) at rest is limited by the critical arterial oxygen content of about 6 ml/dl corresponding to a hemoglobin concentration of 4.4 g/dl. This critical oxygen content is derived from the arteriovenous oxygen difference of the myocardium, assumed that the coronary blood flow is increased by 100% and the available oxygen is utilized nearly totally. Furthermore, extreme hemodilution leads to a dilution acidosis when bicarbonate free solutions are used for hemodilution. This acidosis may decrease both peripheral resistance and mean arterial blood pressure.
Normovolemic hemodilution under normoxic conditions (arterial oxygen partial pressure normal) at rest is limited by the critical arterial oxygen content of about 6 ml/dl corresponding to a hemoglobin concentration of 4.4 g/dl. This critical oxygen content is derived from the arteriovenous oxygen difference of the myocardium, assumed that the coronary blood flow is increased by 100% and the available oxygen is utilized nearly totally. Furthermore, extreme hemodilution leads to a dilution acidosis when bicarbonate free solutions are used for hemodilution. This acidosis may decrease both peripheral resistance and mean arterial blood pressure.