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[Preoperative plasmapheresis].

W Schleinzer1, H H Mehrkens, B von Bormann

  • 1Abteilung für Anästhesiologie, Intensiv- und Transfusionsmedizin, Endoklinik Hamburg/Wintermoor.

Klinische Wochenschrift
|January 1, 1988
PubMed
Summary
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Preoperative plasmapheresis, as part of the Ulm Autologous Transfusion Concept, safely prepares patients by collecting autologous plasma. This method shows no adverse effects on vital signs and normalizes key lab parameters within 24 hours.

Area of Science:

  • Transfusion Medicine
  • Surgical Preparation

Context:

  • Plasmapheresis is a key component of the Ulm Autologous Transfusion Concept (ATU) for preoperative patient preparation.
  • Autologous plasma is collected on an outpatient basis weeks to months prior to surgery.
  • Collected plasma is shock-frozen and stored at -30°C or lower.

Purpose:

  • To evaluate the effects of preoperative plasmapheresis on patient homeostasis and coagulation factors.
  • To assess the safety and efficacy of autologous plasma donation and transfusion in a large patient cohort.
  • To determine the impact of autologous fresh frozen plasma transfusion on postoperative outcomes.

Summary:

  • A study of 813 patients over 1.25 years investigated plasmapheresis effects on homeostasis and coagulation.
  • Volume substitution with Ringer-lactate solution was used; arterial blood pressure and heart rate remained stable.

Related Experiment Videos

  • Transient decreases in laboratory parameters were tolerable, with normalization of protein, antithrombin III, and IgG within 24 hours.

    • Impact:

    • Over three years and 2600+ patients, plasmapheresis is deemed safe for non-fasting outpatients.
    • Postoperative transfusion of autologous fresh frozen plasma serves as effective volume substitution.
    • Key blood components in transfused plasma may reduce risks of thrombosis, embolism, infection, and improve wound healing.