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Updated: Jan 1, 2026
06:53
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
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Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment
Gal Manella1, Rona Aviram1, Nityanand Bolshette2
1Department of Biomolecular Sciences, Weizmann Institute of Science, 7610001 Rehovot, Israel.
Summary
Hypoxia disrupts the body's internal clock, causing circadian misalignment. This misalignment, seen in conditions like obstructive sleep apnea (OSA), may contribute to disease.
Area of Science:
- Chronobiology
- Physiology
- Molecular Biology
Background:
- Disorders causing hypoxic spells, such as asthma, COPD, and obstructive sleep apnea (OSA), show daily variations.
- The interaction between the body's response to low oxygen (hypoxia) and its internal circadian clock is not fully understood.
Purpose of the Study:
- To investigate the interplay between the hypoxic response and the circadian clock in vivo.
- To determine if hypoxia influences circadian clock function and causes misalignment between tissues.
Main Methods:
- Examined the global transcriptional response to acute hypoxia across different tissues.
- Assessed the impact of hypoxia on clock gene expression and function.
- Utilized intermittent hypoxia models relevant to OSA.
Main Results:
- The transcriptional response to hypoxia is tissue-specific and depends on the time of day.
- Hypoxia causes phase shifts in circadian clocks in a tissue-dependent manner, leading to intertissue misalignment.
- Intermittent hypoxia, a model for OSA, also induced circadian misalignment.
Conclusions:
- Hypoxia disrupts circadian clock synchrony, leading to intertissue circadian clock misalignment.
- This hypoxia-induced circadian misalignment may contribute to the pathophysiology of obstructive sleep apnea and other related diseases.
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