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Neoplasms in NIH type II athymic (nude) mice.

D A Sadoff1, W E Giddens, R F DiGiacomo

  • 1Division of Animal Medicine, School of Medicine, University of Washington, Seattle 98195.

Laboratory Animal Science
|August 1, 1988
PubMed
Summary

Athymic (nude) mice develop significantly more neoplasms, particularly lymphosarcomas, than heterozygous mice. This highlights the increased tumor susceptibility in immunodeficient mouse models for research.

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Area of Science:

  • Immunology
  • Oncology
  • Pathology

Background:

  • Athymic (nude) mice (nu/nu) are widely used in biomedical research due to their immunodeficiency.
  • Understanding spontaneous tumor development in these models is crucial for accurate interpretation of experimental results.
  • NIH type II athymic mice and their heterozygous counterparts (nu/+) were examined to assess tumor incidence.

Purpose of the Study:

  • To investigate and compare the incidence of spontaneous neoplasms in NIH type II athymic (nude) mice and NIH type II mice heterozygous at the nu locus.
  • To identify the types and prevalence of tumors in these distinct mouse populations.

Main Methods:

  • Necropsy and histopathological examinations were conducted over an 18-month period.
  • A total of 173 athymic (nu/nu) mice and 53 heterozygous (nu/+) mice were analyzed.
  • Mice were utilized in tumor transplantation studies and colony quality assurance screening.

Main Results:

  • Twenty-nine neoplasms were identified in 173 athymic (nu/nu) mice.
  • Only one neoplasm (ovarian granulosa cell tumor) was found in 53 heterozygous (nu/+) mice.
  • The predominant tumors in nu/nu mice were lymphosarcomas (19), followed by ovarian granulosa cell tumors (9) and a transitional cell carcinoma.
  • Lymphosarcomas were more frequent in nu/nu mice older than 6 months.

Conclusions:

  • Athymic (nude) mice exhibit a significantly higher incidence of spontaneous neoplasms compared to heterozygous mice.
  • Lymphosarcomas are the most common tumor type in athymic mice, with increased occurrence in older animals.
  • These findings underscore the importance of considering spontaneous tumor development when using athymic mice in research, especially in oncology and immunology studies.

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