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Updated: Jan 1, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
Genome-Wide Composite Interval Mapping (GCIM) of Expressional Quantitative Trait Loci in Backcross Population
1Crop Information Center, College of Plant Science and Technology, Wuhan, P. R. China. soyzhang@mail.hzau.edu.cn.
Abstract:
One of the most remarkable findings in expressional quantitative trait locus (eQTL) mapping is that trans (distal) eQTL has small effect. The widely used approaches have a low power in the detection of small-effect eQTL. To overcome this issue, we integrate polygenic background control with multi-locus genetic model to develop genome-wide composite interval mapping (GCIM). This chapter covers the GCIM procedure in a backcross or doubled haploid populations. We describe the genetic model, parameter estimation, multi-locus genetic model, hypothesis tests, and software. Finally, some issues related to the GCIM method are discussed.
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