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Progesterone receptors regulate gallbladder motility.

F S Hould1, G M Fried, A G Fazekas

  • 1Department of Surgery, Montreal General Hospital Research Institute, McGill University, Quebec, Canada.

The Journal of Surgical Research
|December 1, 1988
PubMed
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Hormonal effects on gallbladder contractility were studied. Progesterone receptors in the gallbladder wall were found to regulate gallbladder function in response to hormones, potentially explaining gallstone incidence in women.

Area of Science:

  • Reproductive Endocrinology
  • Gastrointestinal Physiology

Background:

  • Gallstones are more common in multiparous women, suggesting a hormonal link.
  • Hormonal influences on gallbladder contractility are not fully understood.

Purpose of the Study:

  • To investigate the presence and role of estrogen and progesterone receptors in guinea pig gallbladders.
  • To correlate receptor levels with gallbladder contractile response to cholecystokinin (CCK).

Main Methods:

  • Studied estrogen and progesterone receptor binding in guinea pig gallbladder cytosol.
  • Measured gallbladder contractile response in vivo following hormonal manipulation.
  • Compared receptor levels and contractility across normal, oophorectomized, and hormone-treated groups.

Main Results:

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  • Normal gallbladders showed low estrogen and progesterone receptor activity.
  • Oophorectomized guinea pigs lacked detectable receptors.
  • Hormone treatment significantly increased progesterone receptors, inversely correlating with CCK-induced gallbladder contraction.

Conclusions:

  • Gallbladders possess progesterone receptors sensitive to hormonal changes.
  • Progesterone receptor concentration regulates gallbladder contractility.
  • These findings may explain increased gallstone risk in women with altered hormonal states.