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Updated: Jan 1, 2026
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
New Trends in Cutaneous Melanoma Surgery
Jacopo Scala1, Aleksandra Vojvodic2, Petar Vojvodic3
1University G. Marconi, Rome, Italy.
Abstract:
The main surgical treatment for melanoma consists in wide surgical excision of the primary lesion and the sentinel node but in recent times management of melanoma is rapidly evolving with the introduction of new systemic therapies, like BRAF inhibitors, MEK inhibitors and antibodies anti-PD-1 that show good results in controlling even advanced stages of the disease. This review aims to present data for the optimal surgical management of patients with malignant melanoma.
Insights
Melanoma management is evolving beyond surgery with new therapies like BRAF inhibitors, MEK inhibitors, and anti-PD-1 antibodies. This review discusses optimal surgical strategies alongside these advancements for advanced melanoma.
Area of Science:
- Oncology
- Dermatology
- Surgical Oncology
Background:
- Wide surgical excision and sentinel node biopsy are traditional melanoma treatments.
- Emerging systemic therapies are transforming melanoma management, including advanced stages.
Purpose of the Study:
- To review current data on optimal surgical management for malignant melanoma patients.
- To integrate surgical strategies with new systemic therapies for melanoma.
Main Methods:
- Literature review of recent advancements in melanoma treatment.
- Analysis of data on surgical excision and systemic therapies (BRAF/MEK inhibitors, anti-PD-1 antibodies).
Main Results:
- Systemic therapies show significant efficacy in controlling advanced melanoma.
- Optimal surgical management needs to be considered alongside new systemic treatments.
Conclusions:
- The evolving landscape of melanoma treatment requires a combined approach of surgery and novel systemic therapies.
- This review provides insights into optimizing surgical care for melanoma patients in the era of targeted and immune therapies.
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