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Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
Rational targeted therapeutics for double-hit lymphoma
Nancy G Azizian1,2, Yuanhui Liu1,2, Lan V Pham3
1Center for Immunotherapy Research, Houston Methodist Research Institute, Houston, TX 77030, USA.
Targeting both MYC and BCL2 oncogenes offers an effective treatment strategy for double-hit lymphomas. This combined approach addresses the key genetic drivers in these aggressive cancers.
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Background:
- Double-hit lymphomas (DHL) are aggressive B-cell neoplasms.
- DHL are characterized by concurrent translocations of MYC and BCL2 genes.
- These genetic alterations confer a poor prognosis and resistance to conventional therapies.
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