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Posterior Segment Ocular Parameters in Children with Familial Mediterranean Fever

ArifÜlkü Yener1, AslıÇelebi Tayfur2

  • 1Department of Ophthalmology, Keçiören Training and Research Hospital, Ankara, Turkey.

Ocular Immunology and Inflammation
|December 19, 2019
PubMed

Insights

Familial Mediterranean fever (FMF) may alter children's foveal vascular structure, affecting blood vessel density in the macula. This autoimmune condition shows potential ocular impacts beyond known organ involvement.

Area of Science:

  • Ophthalmology
  • Rheumatology
  • Genetics

Background:

  • Familial Mediterranean fever (FMF) is a genetic autoinflammatory disease.
  • Ocular manifestations of FMF are not fully understood, particularly in children during remission.

Purpose of the Study:

  • To compare posterior ocular layer measurements in children with FMF during remission against healthy controls.
  • To investigate potential subclinical ocular changes in pediatric FMF patients.

Main Methods:

  • Swept source optical coherence tomography angiography was used to assess ocular structures.
  • Measurements included retinal nerve fiber layer, optic nerve head, macular layers, vascular densities, avascular zones, and choroidal thickness.
  • 20 pediatric FMF patients and 20 age-matched controls were included.

Main Results:

  • Children with FMF showed significantly higher temporal parafoveal vessel density (49.20% vs 47.14%, p=0.04).
  • Nasal parafoveal vessel density was significantly lower in FMF patients (42.88% vs 46.76%, p=0.02).

Conclusions:

  • FMF, an autoimmune disease, may impact the foveal vascular structure in children.
  • These findings suggest potential ocular involvement in FMF beyond other organ systems.

Keywords:
Choroidal thicknessfamilial Mediterranean feverfoveal vessel densityoptic nerve headswept source optical coherence tomography

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