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A Murine Tail Lymphedema Model

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Is Immediate Lymphatic Reconstruction Cost-effective?

Anna Rose Johnson¹, Ammar Asban², Melisa D Granoff¹

¹Division of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Annals of Surgery

|December 19, 2019

Summary

This summary is machine-generated.

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Cost-Utility Analysis of Indocyanine Green Versus Methylene Blue for Sentinel Lymph Node Biopsy in Breast Cancer.

Journal of surgical oncology·2026

Adding the lymphatic microsurgical preventive healing approach (LYMPHA) to axillary lymph node dissection (ALND) or ALND with regional lymph node radiation (RLNR) improves cost-effectiveness for breast cancer patients. This approach is more cost-effective in preventing lymphedema.

Area of Science:

Health Economics
Surgical Oncology
Lymphedema Management

Background:

Breast cancer-related lymphedema is a significant complication affecting survivors in the US.
Current treatment options for node-positive breast cancer include axillary lymph node dissection (ALND) and ALND with regional lymph node radiation (RLNR).
The lymphatic microsurgical preventive healing approach (LYMPHA) is a surgical technique aimed at preventing lymphedema.

Observation:

A cost-utility analysis was performed comparing ALND, ALND with LYMPHA, ALND with RLNR, and ALND with RLNR plus LYMPHA.
Lymphedema rates were extracted from a meta-analysis, and procedural costs were based on Medicare reimbursement rates.
Quality-adjusted life years (QALYs) were calculated using utility scores from a visual analog scale.

Findings:

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A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

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A Murine Tail Lymphedema Model

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A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

ALND with LYMPHA demonstrated a more cost-effective outcome with an incremental cost-utility ratio (ICUR) of $1587.73/QALY.
The addition of LYMPHA to ALND with RLNR was also more cost-effective, with an ICUR of $699.84/QALY.
Sensitivity analyses confirmed the robustness of these findings.

Implications:

The study suggests that incorporating LYMPHA into ALND or ALND with RLNR is a more cost-effective strategy for managing node-positive breast cancer patients.
This approach may help reduce the incidence and burden of breast cancer-related lymphedema.
Findings support the integration of LYMPHA as a valuable component in breast cancer treatment protocols to improve patient outcomes and quality of life.