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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Formation of the Platelet Plug01:22

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
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Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

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Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
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[Proinflammatory activity of monocytes and activity of glutathione-dependent enzymes in red blood cells in women with depressive conditions].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2024
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Updated: Jan 1, 2026

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

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[Platelets, hemostasis and mental disorders].

E F Vasilyeva1, O S Brusov1

  • 1Mental Health Research Center, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|December 19, 2019
PubMed
Summary

Platelet activation is linked to mental illnesses like schizophrenia and depression, increasing risks for cardiovascular disease and blood clots. Understanding these biochemical links can improve treatment strategies for patients.

Keywords:
coagulationfibrinolysishemostasismental disordersplatelets

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Hematology

Background:

  • Platelets offer an accessible model for studying mental disease biochemical mechanisms.
  • Mental illnesses such as schizophrenia and depression involve complex biochemical pathways.
  • Platelet activation is increasingly recognized as a factor in mental health disorders.

Purpose of the Study:

  • To review the role of platelet activation in the pathogenesis of mental diseases.
  • To explore the association between platelet activation and clinical outcomes in mental disorders.
  • To highlight the potential of platelet research in understanding and treating mental illnesses.

Main Methods:

  • Literature review of existing studies on platelet function and mental health.
  • Analysis of biochemical mechanisms linking platelet activation to psychiatric conditions.
  • Synthesis of data on the clinical consequences of platelet activation in mental illness.

Main Results:

  • Platelet activation is observed in patients with schizophrenia, depression, and other mental illnesses.
  • This activation is associated with increased cardiovascular disease risk and thrombotic complications.
  • These complications represent a significant cause of morbidity and mortality in individuals with mental disorders.

Conclusions:

  • Platelet activation plays a role in the pathogenesis of mental diseases.
  • Understanding these biochemical processes is crucial for managing clinical consequences.
  • Targeting platelet mechanisms may offer novel therapeutic strategies for mental health patients.