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Plasma membrane tension regulates eisosome structure and function.

Daniel Appadurai¹, Lincoln Gay¹, Akshay Moharir¹

¹Henry Eyring Center for Cell and Genome Science, University of Utah, Salt Lake City, UT 84112.

Molecular Biology of the Cell

|December 19, 2019

Summary

This summary is machine-generated.

Eisosomes, yeast cell structures, adapt their shape in response to membrane tension. This dynamic morphology regulates both membrane stress and nutrient transporter levels, coordinating cellular responses to environmental changes.

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Area of Science:

Cell biology
Biophysics
Yeast genetics

Background:

Eisosomes are plasma membrane invaginations in yeast.
They are implicated in membrane stress response and nutrient transporter regulation.
Their precise role in coordinating these pathways remains unclear.

Purpose of the Study:

To investigate the role of eisosomes in response to varying membrane tension.
To determine how eisosome morphology affects cellular pathways.
To elucidate the coordination between membrane tension and nutrient transporter stability.

Main Methods:

Yeast cell culture under various stress conditions (alkaline, osmotic, glucose starvation).
Microscopy techniques to observe eisosome morphology and cell volume.
Analysis of nutrient transporter localization and abundance.

Main Results:

Plasma membrane tension directly influences eisosome morphology (flattening or deepening).
Alkaline stress flattens eisosomes, promoting nutrient transporter downregulation.
Cell shrinking deepens eisosomes, protecting nutrient transporters from endocytosis.

Conclusions:

Eisosomes act as a mechanosensitive platform coordinating membrane stress and nutrient transporter homeostasis.
Eisosome morphology is a key regulator linking physical membrane changes to cellular function.
This study reveals a novel mechanism for cellular adaptation to environmental stress.