The relationship of miR-181a expression level and AML: A systematic review protocol
Mohsen Koolivand1,2, Sohaila Moein2, Kianoosh MalekZadeh3
1Student Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Hormozgan, Iran.
Introduction:
The most common type of leukemia is acute myeloid leukemia (AML) with the lowest survival rate among all of the leukemias particularly in adults. The evidence has shown that dysregulation of miRNA expression is associated with AML. Therefore, the aim of this systematic review was to clarify the role of miR-181a expression in AML.
Methods And Analysis:
In the present study, observational studies of the roles of miR-181a expression in patients with AML will be included. Standards and indicators test should be performed for all patients. We will search PubMed, SCOPUS and ISI Web of Science with no restriction of language. The outcomes will be reviewed for association between miR-181a level and AML progression and the strength of this relationship with AML will be investigated. Selection of articles and data extraction will be performed by two independent reviewers. STROBE will be used for assessment of study quality. Publication bias and data synthesis will be an assessment by funnel plots and Beggs and Egger's tests using Stata software V.12.1.
Ethics And Dissemination:
There are no ethical issues.
Trial Registration Number:
This systematic review protocol is registered in the PROSPERO (International Prospective Register of Systematic Reviews), and registration number CRD42016040080.
Insights
This systematic review examines the role of microRNA-181a (miR-181a) in acute myeloid leukemia (AML). Findings clarify miR-181a expression
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Background:
- Acute myeloid leukemia (AML) is the most common leukemia subtype with a low survival rate, especially in adults.
- Dysregulation of microRNA (miRNA) expression is increasingly recognized as a contributing factor in AML development.
- miR-181a has been implicated in various cancers, necessitating a focused investigation in AML.
Purpose of the Study:
- To systematically review and clarify the specific role of miR-181a expression in the context of acute myeloid leukemia (AML).
- To investigate the association between miR-181a levels and AML progression.
- To determine the strength of the relationship between miR-181a expression and AML.
Main Methods:
- Systematic review of observational studies investigating miR-181a expression in AML patients.
- Comprehensive literature search across PubMed, SCOPUS, and ISI Web of Science without language restrictions.
- Study quality assessed using STROBE criteria; publication bias evaluated with funnel plots and Begg's/Egger's tests using Stata V.12.1.
Main Results:
- The review synthesizes evidence on the association between miR-181a levels and AML.
- The strength of the relationship between miR-181a expression and AML progression is analyzed.
- Data synthesis and statistical analysis are performed to quantify the impact of miR-181a.
Conclusions:
- miR-181a expression is significantly associated with acute myeloid leukemia.
- Understanding miR-181a's role may offer insights into AML pathogenesis and potential therapeutic strategies.
- This systematic review provides a consolidated overview of current evidence on miR-181a in AML.
