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Harnessing MerTK agonism for targeted therapeutics

Vivekananda Kedage1, Diego Ellerman2, Yongmei Chen3

  • 1Department of Molecular Oncology, Genentech, South San Francisco, CA, USA.

Mabs
|December 20, 2019
PubMed

Phagocytosis plays important roles both in homeostasis and under pathological conditions. Fcγ receptor-mediated phagocytosis has been exploited as an integral mechanism for antibody-based therapies. Unlike Fcγ receptor-mediated phagocytosis, MerTK-mediated phagocytic clearance is immunologically silent. Here, we describe a bispecific antibody approach to harness MerTK for targeted clearance without inducing proinflammatory cytokine release associated with Fcγ receptor engagement. We generated bispecific antibodies targeting live B cells or amyloid beta aggregates to demonstrate the feasibility and versatility of this new approach.

Keywords:
Fcγ receptorMerTKPhagocytosisbispecific antibodyimmunologically silent

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