Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Asbestos cement dust inhalation by hamsters.

A P Wehner1, G E Dagle, W C Cannon

  • 1Department of Biology, Battelle, Pacific Northwest Laboratories, Richland, Washington 99352.

Environmental Research
|December 1, 1978
PubMed
Summary

Asbestos cement inhalation caused dose-dependent lung fibrosis in hamsters, with no significant impact on mortality or cancer development. Lung inflammation markers increased with higher exposure levels and durations.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A particulate isotopic standard of plutonium in an aluminosilicate matrix.

Journal of the American Society for Mass Spectrometry·2013
Same author

USTUR whole body case 0262: 33-y follow-up of PuO2 in a skin wound and associated axillary node.

Radiation protection dosimetry·2008
Same author

Spontaneous terminal ileitis resembling Crohn disease in captive tamarins.

Journal of medical primatology·2002
Same author

Two-step model for the risk of fatal and incidental lung tumors in rats exposed to radon.

Radiation research·1999
Same author

Clinical progression of transplanted large granular lymphocytic leukemia in Fischer 344 rats exposed to 60 Hz magnetic fields.

Bioelectromagnetics·1999
Same author

Statistical modeling of carcinogenic risks in dogs that inhaled 238PuO2.

Radiation research·1998

Area of Science:

  • Environmental Health
  • Toxicology
  • Pulmonary Pathology

Background:

  • Occupational exposure to asbestos cement poses risks to respiratory health.
  • Understanding asbestos cement's long-term effects requires controlled animal studies.
  • Previous research established methods for asbestos cement dust inhalation models.

Purpose of the Study:

  • To investigate the pulmonary effects of chronic asbestos cement aerosol inhalation in Syrian golden hamsters.
  • To determine dose-response relationships for asbestos cement exposure.
  • To evaluate the impact of exposure duration and recovery periods on lung pathology.

Main Methods:

  • Male Syrian golden hamsters were exposed to asbestos cement aerosol at 1 and 10 micrograms/liter.
  • Animals were sacrificed at 3, 6, and 15 months, with some groups undergoing recovery periods.

Related Experiment Videos

  • Lung tissues were analyzed for macrophages, ferruginous bodies, and fibrosis.

    • Main Results:

    • Asbestos cement exposure did not significantly affect hamster body weight or mortality.
    • Increased aerosol concentration and exposure duration led to higher lung macrophage and ferruginous body counts.
    • A significant dose-response relationship was observed for lung fibrosis, evident even after withdrawal from exposure.

    Conclusions:

    • Chronic asbestos cement inhalation induces lung fibrosis in a dose-dependent manner.
    • Fibrosis progression continued even after exposure cessation.
    • No primary lung cancers or mesotheliomas were detected in this study.