Related Experiment Video
Updated: Jan 1, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
Published on: June 28, 2019
Left Main Coronary Artery Thrombus Diagnosed and Managed With Coronary Computed Tomography Angiography and Fractional
Shone O Almeida1, Nasih M Ahmed2, Ronald P Karlsberg1,3
1Cardiovascular Research Foundation of Southern California, Beverly Hills, CA, USA.
Insights
Left main coronary artery thrombus (LMCA-T) was diagnosed using coronary computed tomography angiography (CTA) in a war zone. This non-invasive approach enabled timely treatment and demonstrated CTA
Area of Science:
- Cardiovascular Imaging
- Interventional Cardiology
Background:
- Left main coronary artery thrombus (LMCA-T) is a rare condition typically diagnosed via invasive coronary angiography (ICA).
- Access to diagnostic procedures like ICA can be severely limited in conflict zones.
Observation:
- A case of LMCA-T was diagnosed using coronary computed tomography angiography (CTA) in a hospital located in a war zone.
- The patient received treatment without undergoing invasive coronary angiography.
Findings:
- Coronary CTA successfully diagnosed LMCA-T, enabling non-invasive management.
- Follow-up CTA confirmed thrombus resolution after 1 month.
- Retrospective fractional flow reserve computed from CT (FFR-CT) indicated the thrombus was not hemodynamically significant.
Implications:
- Coronary CTA serves as a viable diagnostic tool for LMCA-T when ICA is unavailable.
- FFR-CT can provide crucial hemodynamic information non-invasively.
- This approach offers a potential solution for managing complex cardiovascular conditions in austere environments.
Abstract:
Left main coronary artery thrombus (LMCA-T) is a rare disease state and diagnosed with invasive coronary angiography (ICA). We present a case of LMCA-T diagnosed with coronary computed tomography angiography (CTA) and treated without ICA in a patient who presented to a hospital in the middle of war zone in Erbil, Iraqi Kurdistan. Coronary CTA performed 1 month later demonstrated resolution of the thrombus. Fractional flow reserve computed from computed tomography (FFR-CT; HeartFlow, Redwood City, CA) performed retrospectively confirmed that the clot was not hemodynamically significant at the time of diagnosis. This case demonstrates the diagnostic capabilities of coronary CTA and FFR-CT when ICA is not readily available.
Related Concept Videos
Imaging Studies for Cardiovascular System V: CT
Acute Coronary Syndrome III: Diagnostic Studies
Coronary Artery Disease V: Interprofessional Care
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
Acute Coronary Syndrome IV: Interprofessional Care
Cardiac Catheterization III: Left Heart Catheterization

